Why Ibuprofen May or May Not Stop Your Period. There is a hormone in your body called prostaglandin. In essence, this is the hormone that helps your smooth muscles (such as muscles in your stomach or uterus) know when to contract and when to relax. What can be done to stop/treat extremely painful and horrible period menstrual cramps (dysmenorrhea)? What is the remedy for menstruation pain. Menstruation for some people can be extremely painful, and a heavy flow makes for an unpleasant period. There are ways to shorten, lighten, or even stop your period, depending on your needs. Does anybody know could ibuprofen stop periods temporarily? Thanks! Thanks! I know this post is from a long time ago however i post for those in the present with similar issues. Pour ma part auparavant j'avais des maux de tête le 1er jour de mes règles. J'avais essayé de prendre de l'ibuprofène mais j'ai vite arrêté car ça me diminuait les saignements. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Fowler on how much ibuprofen do you take to stop period: Ibuprofen is used to control pain during menstruation, it is not used to actually stop a menstrual period. Taking NSAID have been linked to decreased menstrual flow, especially Mefenamic Acid (ponstel), but not. Ibuprofen works by inhibiting prostaglandins, which are the cause of the uterine contractions that cause bleeding during your period. Taking a high dose of ibuprofen can, in fact, suppress those prostaglandins enough to actually delay your period. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Glassman on can ibuprofen stop your period: Ibuprofen will no stop your period but will make your period lighter. Ibuprofen works by blocking the pathway (known as Arachidonic Acid Pathway) through which it reduces the amount of Prostaglandin in body. Reduction in enzymatic levels causes its functions to reduce. NO! Don’t do that! Large dose of ibuprofen can seriously damage your stomach. If you want to stop menstrual periods temporarily, you must take different kind of medicaments.